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Aklief Cream (trifarotene)

Indications

• Aklief Cream is used for the topical treatment of acne vulgaris in patients aged 9 years and older.
• It helps reduce the number and severity of acne pimples and promotes quick healing of pimples that do develop.
• Aklief Cream is effective for treating both facial and trunk acne.

Dosage and Administration

• Use Aklief Cream exactly as prescribed by your doctor, typically once daily in the evening.
• Cleanse and dry the affected area before applying a thin layer of Aklief Cream.
• Use only a pea-sized amount of cream to cover the entire face or affected area.
• Wash your hands immediately after applying the cream.
• Follow your doctor’s instructions regarding the duration of therapy and any other skincare products you may use.
• Do not use Aklief Cream more frequently than prescribed, as this can increase the risk of skin irritation.
• Avoid applying Aklief Cream to cuts, abrasions, eczematous, or sunburned skin.
• Avoid contact with eyes, lips, and mucous membranes; rinse thoroughly with water if contact occurs.

Mechanism of Action

Aklief Cream contains Trifarotene, which is a retinoid. It works by modulating the differentiation and proliferation of skin cells, reducing inflammation, and decreasing the formation of acne lesions. Trifarotene specifically targets retinoic acid receptors (RARs) in the skin, helping to clear acne and prevent future breakouts.

Contraindications

• Do not use Aklief Cream if you are allergic to Trifarotene or any of its ingredients.
• Avoid using Aklief Cream on eczematous or sunburned skin, as it can worsen these conditions.
• Do not use the cream if you are pregnant or planning to become pregnant without consulting your doctor.

Side Effects

Common Side Effects:

• Skin irritation
• Dryness
• Redness
• Scaling
• Itching

Serious Side Effects:

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, and trouble breathing
• Severe skin irritation or blistering
• Unusual changes in skin color

Precautions

• Inform your doctor about all other medications you are using, including over-the-counter products and supplements.
• Notify your doctor if you have a history of eczema or other skin conditions.
• Use sunscreen and protective clothing when outdoors to avoid increased sensitivity to sunlight.
• Avoid using other potentially irritating topical products, such as harsh soaps, cleansers, or cosmetics, without consulting your doctor.
• If you experience severe skin irritation, discontinue use and consult your doctor.

Storage Instructions

• Store Aklief Cream at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the cream tube tightly closed when not in use.
• Store it out of reach of children and pets.
• Protect the cream from freezing and excessive heat.

References

https://www.aklief.com/prescribing-information