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Aczone (dapsone) 

Indications 

• Aczone is used to treat acne vulgaris in individuals 12 years of age and older. 
• It helps reduce the number of acne lesions and inflammation associated with acne. 
• Aczone is effective in managing both inflammatory and non-inflammatory acne. 

Dosage and Administration 

• Use Aczone exactly as prescribed by your doctor, usually applied once or twice daily. 
• Cleanse the affected area with a mild soap and water, then pat dry before applying the gel. 
• Apply a thin layer of Aczone to the entire affected area, not just the individual pimples. 
• Wash your hands thoroughly after applying the gel. 
• Continue using Aczone for the full duration of treatment, even if your acne improves before the end of the prescribed period. 
• Do not apply Aczone to broken or irritated skin. 
• Avoid contact with your eyes, mouth, and mucous membranes. If contact occurs, rinse thoroughly with water. 
• Do not use more than the prescribed amount or apply more frequently, as this will not improve results and may increase the risk of side effects. 
• Avoid using other acne medications on the treated area unless directed by your doctor. 
• Do not expose the treated area to excessive sunlight or artificial UV light without protection. 

Mechanism of Action 

Aczone contains dapsone, an antibiotic that works by inhibiting the growth of bacteria and reducing inflammation. It is thought to interfere with the synthesis of bacterial folic acid, which is necessary for bacterial growth. By reducing the bacterial population on the skin and inflammation, Aczone helps clear up acne lesions and prevent new ones from forming. 

Contraindications 

• Do not use Aczone if you are allergic to dapsone or any of its ingredients. 
• Avoid Aczone if you have a history of drug-induced hemolytic anemia (destruction of red blood cells) or methemoglobinemia (a blood disorder). 

Side Effects 

Common Side Effects 

• Dryness 
• Redness 
• Oiliness 
• Peeling 
• Itching 

Serious Side Effects 

• Severe skin reactions, such as blistering or severe peeling 
• Signs of hemolytic anemia, such as unusual tiredness, yellowing of the skin or eyes, dark urine 
• Methemoglobinemia symptoms, including shortness of breath, fatigue, and bluish skin color 

Precautions 

• Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements, especially other topical treatments. 
• Notify your doctor if you have a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency, as Aczone can increase the risk of hemolytic anemia. 
• Report any severe or persistent skin irritation to your doctor immediately. 
• Avoid unnecessary or prolonged exposure to sunlight and use sunscreen or protective clothing when outdoors. 
• If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Aczone with your doctor. 

Storage Instructions 

• Store Aczone at room temperature, between 20°C to 25°C (68°F to 77°F). 
• Keep the tube tightly closed when not in use. 
• Store Aczone out of reach of children and pets. 
• Do not freeze Aczone. 
• Dispose of any unused Aczone after the expiration date on the tube. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/207154s004lbl.pdf