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Prednisolone (Prednisolone)

Indications

• Prednisolone is used to treat various inflammatory and autoimmune conditions, such as arthritis, lupus, and psoriasis.
• It helps manage severe allergies and asthma by reducing inflammation.
• Prednisolone is prescribed for certain types of cancer to help alleviate symptoms.
• It treats conditions involving the eyes, skin, lungs, stomach, and blood by reducing inflammation and suppressing the immune system.
• Prednisolone is used to manage adrenal insufficiency (Addison’s disease) by replacing insufficient steroid hormones.

Dosage and Administration

• Take prednisolone exactly as prescribed by your doctor, usually once or multiple times daily.
• Take it with food or milk to prevent stomach upset. If prescribed a single daily dose, take it in the morning to mimic your body’s natural rhythm.
• Follow the prescribed schedule closely and complete the full course, even if you feel better.
• Have regular check-ups with your doctor to monitor your progress and adjust the dosage if necessary.
• Do not skip doses or suddenly stop taking prednisolone without consulting your doctor, as this can cause withdrawal symptoms.
• Avoid exposure to infections like chickenpox or measles, as prednisolone suppresses your immune system.
• Do not take prednisolone if you have a systemic fungal infection unless directed by your doctor.
• Do not take more than the prescribed dose, as it can increase the risk of severe side effects.
• Do not drink alcohol excessively while taking prednisolone, as it can increase the risk of stomach bleeding.

Mechanism of Action

Prednisolone works by mimicking the effects of cortisol, a natural steroid produced by your adrenal glands. It reduces inflammation by suppressing the migration of white blood cells to inflamed areas and inhibiting the release of substances that cause inflammation. Prednisolone also suppresses the immune system, which helps control autoimmune conditions where your body mistakenly attacks its tissues.

Contraindications

• Do not take prednisolone if you have a systemic fungal infection.
• Avoid prednisolone if you have a known allergy to prednisolone or any of its ingredients.
• Do not use prednisolone if you have untreated serious infections, such as tuberculosis, unless directed by your doctor.
• Avoid taking prednisolone if you have peptic ulcers or a history of severe psychiatric disorders without consulting your doctor.

Side Effects

Common Side Effects

• Increased appetite
• Weight gain
• Insomnia
• Mood changes
• Stomach upset

Serious Side Effects

• High blood pressure
• Increased risk of infections
• Osteoporosis (bone thinning)
• Muscle weakness
• Vision problems (such as cataracts or glaucoma)

Precautions

• Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements.
• Contact your doctor if you experience severe mood changes, vision problems, or signs of infection (such as fever, or sore throat).
• Have regular check-ups to monitor for potential side effects, including blood pressure and bone density.
• Avoid contact with people who have infections like chickenpox or measles.
• Monitor blood sugar levels if you have diabetes, as prednisolone can increase blood sugar levels.
• Let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.

Storage Instructions

• Store prednisolone at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep the tablets in a dry place and in their original container, tightly closed.
• Store prednisolone out of reach of children and pets.

References

https://www.drugs.com/pro/prednisolone-tablets.html