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Livalo (pitavastatin)

Indications

• Livalo is used to lower high levels of cholesterol in the blood, particularly LDL cholesterol.
• It is prescribed to reduce the risk of heart attack and stroke in individuals with risk factors such as type 2 diabetes or existing heart disease.
• Livalo helps manage mixed dyslipidemia by lowering LDL cholesterol and triglycerides while increasing HDL cholesterol.

Dosage and Administration

• Take Livalo exactly as prescribed by your healthcare provider.
• Take once a day, with or without food.
• Take at the same time each day to maintain even levels of the drug in your bloodstream.
• Test your cholesterol levels and liver function regularly as advised by your doctor.
• Do not take an extra dose to make up for a missed dose; just take the next dose at the regular time.
• Do not consume grapefruit or grapefruit juice while taking Livalo as it can increase the risk of side effects.
• Avoid excessive alcohol consumption, as it can increase the risk of liver damage.

Mechanism of Action

Livalo (pitavastatin) works by inhibiting HMG-CoA reductase, an enzyme involved in the production of cholesterol in the liver. By blocking this enzyme, Livalo reduces the amount of cholesterol synthesized, leading to lower levels of LDL (bad) cholesterol and triglycerides in the blood while increasing levels of HDL (good) cholesterol. This helps prevent the buildup of cholesterol plaques in arteries, reducing the risk of cardiovascular events.

Contraindications

• Allergy to Pitavastatin: Do not use it if you have a known allergy to Pitavastatin or any other ingredients in the tablet.
• Active Liver Disease: Should not be used in patients with active liver disease or unexplained persistent elevations of liver enzymes.
• Pregnancy: Contraindicated in pregnant women due to the risk of harm to the unborn baby.
• Breastfeeding: Do not use the medication while breastfeeding as it may pass into breast milk and harm the nursing infant.
• Severe Renal Impairment: Not recommended for patients with severe kidney problems without careful monitoring.

Side Effects

Common Side Effects:

• Headache
• Muscle pain
• Diarrhea
• Joint pain
• Constipation
• Back pain

Serious Side Effects:

• Severe muscle pain or weakness (myopathy/rhabdomyolysis)
• Liver problems (jaundice, dark urine, severe fatigue)
• Allergic reactions (hives, difficulty breathing, swelling of face or throat)
• Kidney problems (reduced urine output, swelling in legs or ankles)
• Severe abdominal pain

Precautions

• Monitor Muscle Symptoms: Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
• Liver Function Tests: Regular liver function tests are necessary to monitor for potential liver damage.
• Drug Interactions: Inform your doctor about all medications and supplements you are taking to prevent interactions.
• Diabetes Management: Be aware that Livalo can increase blood sugar levels; diabetic patients should monitor their blood glucose closely.

Storage Instructions

• Store Livalo at room temperature between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and light.
• Keep the tablets in their original packaging until ready to use.
• Ensure the medication is stored safely away from children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/022363s020lbl.pdf