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Persantine (dipyridamole)

Indications

• Persantine is used to prevent blood clots after heart valve replacement surgery. It helps keep the blood flowing smoothly.
• Used in combination with other medications to reduce the risk of stroke in patients with a history of blood clots.
• Employed during stress testing for the heart to help diagnose coronary artery disease.

Dosage and Administration

• Take Persantine exactly as prescribed by your doctor.
• Swallow the tablets whole with a full glass of water.
• Take the medication at the same time every day to maintain an even level in your bloodstream.
• Inform your doctor of all medications you are currently taking to avoid interactions.
• Follow a heart-healthy diet and exercise routine as advised by your healthcare provider.
• Do not crush or chew the tablets as it can alter the drug’s effectiveness.
• Avoid missing doses; take it as soon as you remember unless it’s almost time for the next dose.
• Do not take double doses to make up for a missed one.
• Do not stop taking Persantine without consulting your doctor, even if you feel well.

Mechanism of Action

Persantine (Dipyridamole) works by inhibiting the uptake of adenosine into platelets, endothelial cells, and erythrocytes. This action increases the local concentrations of adenosine, which is a vasodilator and inhibitor of platelet aggregation. By preventing the platelets from sticking together, it helps prevent blood clots and improves blood flow.

Contraindications

• Do not use the medication if you are allergic to Dipyridamole or any ingredients in Persantine.
• Avoid if you have a condition that involves active bleeding.
• Not recommended if you have severe coronary artery disease.
• Consult your doctor if you have liver or kidney problems before taking this medication.
• Inform your healthcare provider if you are pregnant or breastfeeding.

Side Effects

Common Side Effects:

• Headache
• Dizziness
• Nausea
• Upset stomach
• Diarrhea
• Flushing

Serious Side Effects:

• Chest pain
• Unusual bleeding or bruising
• Severe headache
• Difficulty breathing
• Allergic reactions (rash, itching, swelling)

Precautions

• Use it with caution if you have low blood pressure or are prone to faint spells.
• Regular monitoring of blood pressure and heart rate is advised while on Persantine.
• Avoid operating heavy machinery or driving if you experience dizziness or drowsiness.
• Discuss all medications, supplements, and herbal products you are taking with your healthcare provider to avoid interactions.

Storage Instructions

• Store Persantine tablets at room temperature between 68°F and 77°F (20°C and 25°C).
• Keep the medication in its original container, tightly closed, and away from moisture and light.
• Do not store it in the bathroom to avoid exposure to humidity.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/012836s061lbl.pdf