Are you Looking to Buy Entresto (Sacubitril/Valsartan) from PrescriptionPoint.

Entresto is a heart medicine used in adults with chronic (long-term) heart failure who have symptoms of the disease and reduced ejection fraction (a measure of how well the heart pumps blood). U.S. customers can buy Entresto from a Canadian online pharmacy like PrescriptionPoint.com. You can also get Sacubitril and Valsartan, the generic alternative. We offer many other high-quality medications and allow you to shop 24 hours a day and 7 days a week. Our website is safe. Prescription Point is certified by Canadian International Pharmacy Association (CIPA). We display the seal to signal that we conform to nothing but the highest standards for quality. Our CIPA affiliate pharmacies are recognized globally as the first choice in prescription and non-prescription medicine.

Prescription Point guarantees the best Canadian price for Entresto.

A prescription must be provided for Entresto as with all prescription medicine. You must fax a copy of your prescription, and then mail the actual original prescription to us. No exceptions. If you have any questions regarding the medication or Prescription Point, you can contact us. If you wish to speak to a customer representative, call our toll-free number 1-877-244-0431. You can call us from Monday to Friday between 6am to 8pm PST and Saturday to Sunday between 7am to 5pm PST.

Indications: Entresto is indicated for

1. Reducing the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most evident in patients with left ventricular ejection fraction (LVEF) below normal. 
2. Treating symptomatic heart failure with systemic left ventricular systolic dysfunction in pediatric patients aged one year and older. ENTRESTO reduces NT-proBNP and is expected to improve cardiovascular outcomes. 

Directions: Take Entresto as prescribed by your healthcare provider and follow the dosage instructions provided by your healthcare provider carefully. Take the medication regularly at the same time each day to derive the most benefit from it. Shake the suspension form well before each dose and use a special measuring device/spoon to ensure the correct dose. Do not adjust the dosage without consulting your healthcare provider. Do not take Entresto with ACE inhibitors and avoid taking it at least 36 hours before or after taking an ACE inhibitor. Do not use a household spoon to measure the dose of the suspension form. 

Mechanism of Action: Entresto works by inhibiting neprilysin, an enzyme responsible for breaking down beneficial peptides in the body. This inhibition leads to increased levels of natriuretic peptides, which promote vasodilation and diuresis. Additionally, Valsartan, an angiotensin II receptor blocker (ARB), blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II, further contributing to its therapeutic effects in heart failure. 

Contraindications: Hypersensitivity to any component of Entresto. History of angioedema related to previous ACE inhibitor (ACEi) or ARB therapy. Concomitant use with ACE inhibitors and Aliskiren in patients with diabetes. 

Side Effects: Less serious side effects include headache, dizziness and cough. Serious side effects includes hyperkalemia, angioedema and hypotension. This is not a complete list of side effects.

Observe for signs and symptoms of angioedema and hypotension. Monitor renal function and potassium levels in susceptible patients. 

Drug Interactions: Tekturna | Midamor | Qulipta | Lotensin

Store Entresto tablets at room temperature between 68°F to 77°F (20°C to 25°C). Protect Entresto tablets from moisture. Store bottles of Entresto oral suspension at room temperature less than 77°F (25°C) for up to 15 days. Do not refrigerate Entresto oral suspension. Keep Entresto out of the reach of children. 

How much can I save by buying Entresto from a Canadian pharmacy compared to U.S. prices? 

Buying Entresto from a Canadian pharmacy can result in significant savings compared to U.S. prices. At Prescription Point, a pack of 56 tablets of 49/51 mg costs $171.20, whereas the same quantity in the U.S. is priced at approximately $635.09. This means you’ll save around 73% compared to U.S. prices. 

How long does shipping take when ordering Entresto online? 

Shipping takes about 2-4 weeks after your order leaves the pharmacy. 

Do I need a valid prescription to buy Entresto online? 

Yes, a valid prescription is required to buy Entresto online. You can mail it to us at Suite #537 102-17750 56 Avenue, Surrey, B.C, Canada V3S 1K4. You can also upload it online. To learn how, visit our how to order page. Another option is to ask your doctor’s office to fax it directly to us at our toll-free number +1-877-453-0921. If you have any questions, feel free to email us at info@prescriptionpoint.com. 

What payment methods are accepted for online Entresto purchases? 

We accept Personal Checks, International Money Orders, Certified Checks, and E-checks. 

What is the return policy for Entresto purchased online? 

Pharmaceutical laws and customer safety prevent us from accepting returns of Entresto purchased online. To make sure you choose the right medication, it is always best to check with your doctor beforehand. 

Can you buy Entresto over the counter? 

Entresto is not available over the counter because it requires careful monitoring by a healthcare professional. Since it has a risk of serious side effects, such as severe allergic reactions, a doctor’s prescription is necessary for safe use. 

References

Prescribing Information. Access.fda.gov. 2021

U.S. Coupon Prices. PharmacyChecker.com. 2025