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Mirapex ER (pramipexole)

Indications

  • Parkinson’s Disease: Mirapex ER is primarily used to treat symptoms of Parkinson’s disease, such as tremors, stiffness, and slowness of movement. It helps improve your ability to move and decreases shakiness, unsteadiness, and the number of “off” periods (times of slow movement or stiffness).
  • Restless Legs Syndrome (RLS): It is also prescribed to manage moderate to severe Restless Legs Syndrome, a condition that causes an uncontrollable urge to move the legs, often accompanied by uncomfortable sensations.

Ingredients

  • Active Ingredient: Pramipexole dihydrochloride
  • Inactive Ingredients: Corn starch, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, povidone, silicon dioxide, stearic acid.

Dosage and Administration

  • Take Mirapex ER tablets once daily, with or without food, as prescribed by your doctor.
  • Swallow the tablet whole; do not crush, chew, or split it, as this can interfere with the extended-release mechanism.
  • Take the missed dose as soon as you remember. If it is near the time of your next dose, skip the missed dose and resume your usual dosing schedule.
  • Do not abruptly stop taking Mirapex ER without consulting your doctor, as this may cause a worsening of symptoms or withdrawal effects.
  • Avoid consuming alcohol while taking this medication, as it may increase the risk of dizziness or drowsiness.
  • Do not take more than the prescribed dose, as this can increase the risk of side effects such as hallucinations or severe drowsiness.

Mechanism of Action

Mirapex ER (Pramipexole) works by mimicking the action of dopamine, a natural substance in the brain that helps control movement. As a dopamine agonist, pramipexole stimulates dopamine receptors in the brain, improving motor function and reducing symptoms of Parkinson’s disease and Restless Legs Syndrome.

Contraindications

  • Avoid using Mirapex ER if you have an allergy to pramipexole or any other ingredients in the tablet.
  • This medication should not be used in patients with a history of compulsive behaviors, such as gambling or overeating, as it may worsen these tendencies.
  • Not recommended for use in patients with severe kidney impairment without dose adjustment, as the drug is primarily excreted by the kidneys.
  • Caution is advised if you have low blood pressure (hypotension) or are prone to sudden drops in blood pressure, as Mirapex ER can exacerbate these conditions.

Side Effects

Common Side Effects:

  • Dizziness
  • Drowsiness
  • Nausea
  • Dry mouth
  • Constipation
  • Swelling in the legs or arms

Serious Side Effects:

  • Hallucinations (seeing or hearing things that are not there)
  • Uncontrollable urges (e.g., gambling, eating, shopping)
  • Severe drowsiness, especially during daytime activities
  • Shortness of breath or chest pain
  • Severe allergic reactions (rash, itching, swelling of the face, lips, or throat)

Precautions

  • Inform your doctor if you have a history of heart problems, kidney disease, or mental health issues before starting Mirapex ER.
  • Be cautious when performing activities that require alertness, such as driving or operating heavy machinery, as this medication can cause drowsiness and sudden sleep episodes.
  • Regular monitoring of blood pressure and kidney function is recommended while on this medication.
  • If you experience any unusual thoughts or behaviors, such as increased compulsive behavior, contact your doctor immediately.
  • Stay hydrated and avoid overheating, as Mirapex ER can cause a drop in blood pressure, especially when standing up.

Storage Instructions

  • Store Mirapex ER tablets at room temperature, away from moisture, heat, and direct light.
  • Keep the medication in its original packaging, tightly closed, and out of reach of children.
  • Do not store in the bathroom or any area with high humidity.

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References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/022421s022lbl.pdf

Additional information

Brand Name:

Mirapex ER

Scientific Name:

Pramipexole

Other Names:

Pexola ER, Pramipex ER, Pramipexole PR, Sifrol ER

Strength(s):

0.75mg, 0.375mg, 1.5mg, 3.75mg, 3mg, 4.5mg

Quantities Available:

30, 90, 100, 180

Formulation:

Extended Release Tablet

The information above is provided by third parties to Prescriptionpoint.com for Mirapex ER (Pramipexole). This information is for general purposes only and is not intended to replace a physician's advice. Always consult with your doctor or a qualified health care professional if you need advice on any medical concerns.


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