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Lovaza (omega-3-acid ethyl esters)

Indications

Lovaza is used to reduce very high triglyceride levels (500 mg/dL or higher) in adults, helping to prevent pancreatitis and other complications associated with elevated triglycerides.

Dosage and Administration

• Take Lovaza exactly as prescribed by your healthcare provider.
• Take the capsules with meals to improve absorption and reduce the likelihood of gastrointestinal discomfort.
• Swallow the capsule whole with a glass of water; do not crush, chew, or break the capsules.
• Take Lovaza at the same time each day to maintain a consistent level in your bloodstream.
• Avoid alcohol consumption, as it can increase triglyceride levels and reduce the effectiveness of Lovaza.
• Do not use Lovaza as the only treatment for high triglycerides without dietary and lifestyle modifications.

Mechanism of Action

Lovaza (omega-3-acid ethyl esters) works by lowering the production of triglycerides in the liver. It contains a combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are omega-3 fatty acids that help reduce triglyceride levels by inhibiting the synthesis of triglycerides and promoting their breakdown.

Contraindications

• Allergy to Omega-3-Acid Ethyl Esters: Do not use the medication if you have a known allergy to Omega-3-acid ethyl esters or any other ingredients in the capsules.
• Fish or Shellfish Allergy: Avoid if you have a severe allergy to fish or shellfish, as Lovaza is derived from fish oil.
• Bleeding Disorders: Use with caution if you have a bleeding disorder or are taking anticoagulant medications, as Lovaza can increase the risk of bleeding.

Side Effects

Common Side Effects:

• Burping
• Upset stomach
• Change in taste
• Back pain

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Signs of bleeding (easy bruising, prolonged bleeding from cuts, unusual bleeding)

Precautions

• Monitor Lipid Levels: Have regular blood tests to monitor your lipid levels and ensure Lovaza is effectively managing your triglycerides.
• Inform About Other Medications: Tell your doctor about all other medications you are taking, including blood thinners and antiplatelet drugs, to avoid potential interactions.
• Pregnancy and Breastfeeding: Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Diabetes: Inform your doctor if you have diabetes, as Lovaza can affect blood sugar levels.
• Regular Check-Ups: Attend regular check-ups to monitor your overall health and response to the medication.

Storage Instructions

• Store Lovaza at room temperature between 20°C to 25°C (68°F to 77°F).
• Store in a dry place, away from moisture and light.
• Keep the capsules in their original container with the cap tightly closed when not in use.
• Ensure the medication is stored safely away from children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021654s043lbl.pdf