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Aygestin (norethindrone)

Indications

Aygestin is indicated for:

• Management of Abnormal Uterine Bleeding: Helps control heavy or irregular menstrual periods by regulating the menstrual cycle.
• Treatment of Endometriosis: Reduces the growth of endometrial tissue outside the uterus, alleviating pain and discomfort.
• Secondary Amenorrhea: Induces menstrual periods in women who have stopped menstruating for several months but are not pregnant or menopausal.
• Contraception: Used in some cases to prevent pregnancy as part of a combined contraceptive regimen.

Dosage and Administration

• Take the tablet exactly as directed by your doctor.
• Take the tablet at the same time every day to maintain an even level of the medicine in your body.
• Take it with or without food based on your preference.
• Do not skip doses. Missing a dose may increase the risk of irregular bleeding or pregnancy if using contraception.
• Do not take two tablets at once if you miss a dose. Follow your doctor’s instructions on what to do if you miss a dose.
• Do not stop suddenly. Stopping the medication without consulting your doctor can cause withdrawal symptoms and irregular bleeding.

Mechanism of Action

Norethindrone, the active ingredient in Aygestin, is a synthetic progestin. It mimics the action of natural progesterone, a hormone that regulates the menstrual cycle and maintains pregnancy. By supplementing or replacing natural progesterone, it helps to normalize menstrual cycles, reduce abnormal uterine bleeding, and alleviate symptoms of endometriosis.

Contraindications

• Pregnancy: Should not be used if you are pregnant, as it can harm the fetus.
• Liver Disease: Contraindicated in patients with liver dysfunction or disease due to potential exacerbation of the condition.
• Hormone-Dependent Cancers: Should not be used in patients with known or suspected cancer of the breast or reproductive organs.
• Undiagnosed Vaginal Bleeding: Avoid use if you have unexplained vaginal bleeding until a diagnosis is made.
• History of Stroke or Blood Clots: Not recommended for individuals with a history of thromboembolic disorders.

Side Effects

Common Side Effects

• Headache
• Nausea
• Breast tenderness
• Irregular menstrual periods
• Dizziness

Serious Side Effects

• Severe headache
• Vision changes
• Swelling or pain in the legs
• Shortness of breath
• Yellowing of the skin or eyes (jaundice)

Precautions

• Regular Check-ups: Schedule routine medical appointments to monitor your condition and response to the medication.
• Blood Pressure Monitoring: Check your blood pressure regularly, as Aygestin can cause an increase in blood pressure.
• Disclose Medical History: Inform your doctor of any personal or family history of blood clots, stroke, heart disease, or cancer.
• Smoking: Avoid smoking, as it increases the risk of serious cardiovascular side effects, especially if you are over 35.
• Diabetes: If you have diabetes, monitor your blood sugar levels closely, as Aygestin can affect glucose tolerance.

Storage Instructions

• Store the tablets at room temperature, between 68°F to 77°F (20°C to 25°C).
• Keep the medication in a dry place, away from moisture and humidity.
• Ensure that the medication is stored securely out of the reach of children.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018405s023lbl.pdf