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Cafergot (ergotamine and caffeine)

Indications

• Cafergot tablets are indicated for the treatment of vascular headaches, including migraines and cluster headaches.
• It works by narrowing the blood vessels in the brain and reducing the pulsation of certain cranial arteries, thereby alleviating migraine symptoms such as throbbing headache, nausea, and sensitivity to light and sound.

Dosage and Administration

• Take Cafergot tablets exactly as prescribed by your doctor, at the first sign of a migraine attack.
• Swallow the tablets whole with a full glass of water.
• Take Cafergot tablets with a small amount of food to minimize stomach upset.
• Follow your doctor’s instructions regarding the appropriate dosage and frequency of Cafergot use.
• Do not crush, chew, or break the tablets.
• Do not exceed the recommended dose of Cafergot or take it more frequently than prescribed.
• Avoid using Cafergot for prolonged periods or for the prevention of migraine attacks, as it may lead to headaches.

Mechanism of Action

Cafergot combines two active ingredients: Ergotamine, an ergot alkaloid, and Caffeine. Ergotamine works by constricting blood vessels in the brain, while caffeine enhances the absorption and effectiveness of ergotamine, leading to vasoconstriction and relief of migraine symptoms.

Contraindications

• Do not use Cafergot if you have a known allergy to Ergotamine, Caffeine, or any other ingredients in the tablets.
• Avoid Cafergot if you have peripheral vascular disease, coronary artery disease, or a history of ischemic heart disease or stroke.
• Consult your doctor before using Cafergot if you are pregnant, breastfeeding, or have a history of drug dependence or abuse.

Side Effects

Common Side Effects:

• Nausea or vomiting
• Dizziness or lightheadedness
• Weakness or fatigue
• Tingling or numbness in the fingers or toes
• Muscle pain or cramps

Serious Side Effects:

• Chest pain or tightness
• Rapid or irregular heartbeat
• Severe abdominal pain
• Vision changes or loss of vision
• Signs of an allergic reaction (rash, itching, swelling, difficulty breathing)

Precautions

• Inform your doctor about any existing medical conditions or medications you are taking before using Cafergot.
• Avoid alcohol while taking Cafergot, as it may increase the risk of side effects such as dizziness or drowsiness.
• Monitor for signs of ergotism (severe peripheral vasoconstriction) with prolonged use of Cafergot, and discontinue the medication if symptoms occur.
• If you experience chest pain or other symptoms of heart problems while taking Cafergot, seek medical attention immediately.

Storage Instructions

• Store Cafergot tablets at room temperature (20°C to 25°C) in a dry place, away from moisture and heat.
• Keep the tablets in their original blister packaging until ready to use.
• Do not use Cafergot if the tablets appear discolored, damaged, or show signs of deterioration.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/9000s22s23lbl.pdf