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Detrol (tolterodine tartrate) 

Indications 

Detrol tablets are used for treating overactive bladder symptoms, such as: 

• Urge urinary incontinence (leakage) 
• Urgency (sudden need to urinate) 
• Frequency (frequent urination) 

Dosage and Administration 

• Take Detrol exactly as prescribed by your doctor. 
• Swallow the tablet whole with water. 
• Take Detrol tablets with or without food. 
• Inform your doctor about any other medications you are taking. 
• Do not crush, chew, or break the tablet. 
• Do not exceed the recommended dose without consulting your doctor. 

Mechanism of Action 

Detrol works by blocking specific receptors in the bladder, which helps to relax the bladder muscles. This reduces the urge to urinate and helps control bladder symptoms like urgency, frequency, and incontinence. 

Contraindications 

• Avoid using Detrol if you have urinary retention. 
• Do not use it if you have gastric retention. 
• Not recommended for patients with uncontrolled narrow-angle glaucoma. 
• Do not use if you have a known allergy to tolterodine or any of its ingredients. 

Side Effects 

Common Side Effects: 

• Dry mouth 
• Headache 
• Dizziness 
• Constipation 
• Stomach pain 

Serious Side Effects: 

• Severe allergic reactions (rash, itching, swelling) 
• Chest pain 
• Difficulty breathing 
• Severe dizziness 
• Trouble urinating 

Precautions 

• Use Desyrel with caution if you have bladder outflow obstruction or gastrointestinal obstructive disorders, as it may cause urinary retention and gastric retention. 
• If you have decreased gastrointestinal motility, be cautious when using Desyrel. 
• Exercise caution if you are being treated for narrow-angle glaucoma while using Desyrel. 
• Adjust the dose of Desyrel to 1 mg twice daily for patients with significantly reduced liver or kidney function. 
• Be cautious when using Desyrel if you have myasthenia gravis, a condition that affects muscle control. 

Storage Instructions 

• Store Detrol tablets at 25ºC (77ºF). 
• Keep away from excessive heat or light. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020771s019,021228s012lbl.pdf