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Prinzide (lisinopril and hydrochlorothiazide)

Indications

Prinzide is used to treat high blood pressure (hypertension). Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems.

Dosage and Administration

• Take Prinzide exactly as prescribed by your healthcare provider.
• Take the tablet at the same time each day, with or without food, to maintain an even level of the medication in your blood.
• Drink plenty of fluids unless otherwise directed by your doctor, as dehydration can increase the risk of side effects.
• Monitor your blood pressure regularly to ensure the medication is working effectively.
• Do not stop taking Prinzide suddenly without consulting your doctor, as this can cause a sudden increase in blood pressure.
• Avoid using salt substitutes or potassium supplements without your doctor’s advice, as Prinzide can increase potassium levels.
• Do not take Prinzide if you are pregnant or planning to become pregnant, as it can harm an unborn baby.
• Do not take it if you have a history of angioedema related to previous ACE inhibitor therapy.

Mechanism of Action

Prinzide combines an angiotensin-converting enzyme (ACE) inhibitor and a thiazide diuretic. Lisinopril blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, relaxing blood vessels and reducing blood pressure. Hydrochlorothiazide helps eliminate excess salt and water from the body, further lowering blood pressure and reducing fluid retention.

Contraindications

• Do not use Prinzide if you have a history of angioedema related to previous ACE inhibitor treatment.
• Avoid if you have severe kidney disease, are unable to urinate, or have an allergy to sulfa drugs.
• Do not use it if you are pregnant, planning to become pregnant, or breastfeeding.
• Not recommended for individuals with a known allergy to lisinopril, hydrochlorothiazide, or any of its ingredients.

Side Effects

Common Side Effects

• Dizziness
• Headache
• Cough
• Fatigue
• Nausea
• Increased urination

Serious Side Effects

• Severe allergic reactions (swelling of the face, lips, tongue, or throat)
• High potassium levels (hyperkalemia)
• Low potassium levels (hypokalemia)
• Kidney problems
• Liver problems (jaundice, elevated liver enzymes)
• Fainting or severe dizziness

Precautions

• Inform your doctor if you have a history of kidney or liver disease, gout, diabetes, or electrolyte imbalances before starting Prinzide.
• Regularly monitor blood pressure, kidney function, and electrolyte levels through scheduled check-ups.
• Stay hydrated but avoid excessive intake of potassium-rich foods and supplements.
• Report any signs of infection (fever, sore throat) to your healthcare provider, as Prinzide can lower white blood cell counts.
• Use caution when driving or operating heavy machinery until you know how Prinzide affects you, as it can cause dizziness.

Storage Instructions

• Store Prinzide tablets at room temperature, between 15°C to 30°C (59°F to 86°F).
• Keep the tablets in their original packaging to protect them from moisture and light.
• Do not store it in the bathroom or near a sink.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019778s047lbl.pdf