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Pennsaid (diclofenac sodium)

Indications

Pennsaid solution is a nonsteroidal anti-inflammatory drug (NSAID) used topically for the treatment of osteoarthritis pain in certain joints, such as the knees.

Dosage and Administration

• Shake the Pennsaid bottle well before use.
• Apply a few drops of Pennsaid directly onto the affected knee(s).
• Gently rub the solution into the skin until it is completely absorbed.
• Wash your hands thoroughly after applying Pennsaid, unless you are treating your hands.
• Do not apply Pennsaid to broken, irritated, or infected skin.
• Avoid covering the treated area with bandages or tight clothing immediately after application.
• Do not use Pennsaid on open wounds or near the eyes, mouth, or mucous membranes.

Mechanism of Action

Pennsaid contains Diclofenac Sodium, which belongs to a class of medications called NSAIDs. It works by inhibiting the production of prostaglandins, substances in the body that play a role in inflammation and pain. By reducing inflammation in the joint, Pennsaid helps relieve osteoarthritis pain.

Contraindications

• Do not use Pennsaid if you are allergic to Diclofenac or any other NSAIDs.
• Avoid Pennsaid if you have a history of asthma, hives, or allergic reactions after taking aspirin or other NSAIDs.
• Pennsaid solution is not recommended for use in children under 18 years old without medical advice.

Side Effects

Common Side Effects:

• Skin irritation at the application site (redness, itching, burning)
• Dry skin
• Rash

Serious Side Effects:

• Severe allergic reactions (difficulty breathing, swelling of the face, lips, tongue)
• Severe skin reactions (blistering, peeling)
• Stomach bleeding or ulceration (symptoms include black or bloody stools, and abdominal pain)

Precautions

• Inform your doctor about any existing skin conditions or allergies before starting treatment with Pennsaid.
• Do not use Pennsaid along with other topical medications in the same area without medical advice.
• Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) while using Pennsaid, as it may increase the risk of skin reactions.

Storage Instructions

• Store Pennsaid solution at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep the bottle tightly closed when not in use and store away from heat and direct sunlight.
• Keep out of reach of children and pets.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204623s000lbl.pdf