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Zestoretic (lisinopril/hctz)

Indications

Zestoretic is used to treat high blood pressure, which helps reduce the risk of strokes, heart attacks, and kidney problems. It combines an ACE inhibitor (lisinopril) with a diuretic (hydrochlorothiazide) to enhance blood pressure control.

Ingredients

• Active Ingredients: Lisinopril, Hydrochlorothiazide.
• Inactive Ingredients: Calcium phosphate, magnesium stearate, starch, pregelatinized starch, and color additives depending on the tablet strength.

Dosage and Administration

• Take Zestoretic exactly as prescribed by your healthcare provider, usually once daily, with or without food.
• Swallow the tablet whole with a full glass of water. It’s best to take this medication in the morning to avoid frequent urination at night.
• Continue taking Zestoretic even if you feel well, as high blood pressure often has no symptoms. Regular use is important for effectiveness.
• Do not discontinue Zestoretic abruptly without consulting your healthcare provider, as this could lead to a sudden spike in blood pressure.
• Avoid consuming alcohol while taking Zestoretic, as it can lower your blood pressure further and increase side effects like dizziness.
• Do not use salt substitutes or potassium supplements unless your doctor has advised, as lisinopril can increase potassium levels in the blood.
• Avoid prolonged exposure to sunlight and use sunscreen, as hydrochlorothiazide can increase your skin’s sensitivity to the sun.

Mechanism of Action

Zestoretic combines two medications to lower blood pressure. Lisinopril, an ACE inhibitor, relaxes blood vessels by blocking the formation of a substance that tightens blood vessels. Hydrochlorothiazide, a diuretic, helps the kidneys remove excess salt and water from the body, reducing fluid buildup and blood pressure.

Contraindications

• Do not use Zestoretic if you are allergic to lisinopril, hydrochlorothiazide, or any other component of the tablet.
• Avoid taking Zestoretic if you have a history of angioedema related to previous ACE inhibitor therapy or if you have hereditary or idiopathic angioedema.
• Zestoretic is contraindicated in patients with anuria (inability to produce urine) or hypersensitivity to sulfonamide-derived drugs.
• This medication should not be used during pregnancy, particularly in the second and third trimesters, due to the risk of harm to the unborn baby.

Side Effects

Common Side Effects:

• Dizziness
• Headache
• Fatigue
• Cough
• Muscle cramps

Serious Side Effects:

• Severe allergic reactions (swelling of the face, lips, or throat)
• Signs of kidney problems (change in urine output, swelling in the feet or ankles)
• High potassium levels (irregular heartbeat, muscle weakness)
• Severe dehydration or electrolyte imbalance
• Low blood pressure (fainting, severe dizziness)

Precautions

• Monitor your blood pressure regularly and inform your healthcare provider of any significant changes.
• Inform your healthcare provider if you have a history of kidney or liver disease, electrolyte imbalances, or heart problems before starting Zestoretic.
• If you experience persistent cough, dizziness, or signs of allergic reactions, contact your healthcare provider promptly.
• Be cautious when getting up from a sitting or lying position, as Zestoretic can cause dizziness, especially when starting the medication.
• If you have diabetes, monitor your blood sugar levels closely, as hydrochlorothiazide can affect blood sugar control.

Storage Instructions

• Store Zestoretic tablets at room temperature, between 68°F to 77°F (20°C to 25°C), in a dry place away from moisture and heat.
• Keep the medication in its original container, tightly closed, to protect it from light and humidity.

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Authenticity and Safety

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Prescription Requirement: We prioritize your well-being by requiring a valid prescription from a healthcare provider, ensuring that Zestoretic is suitable for your condition.

Cost and Savings

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Generic Alternatives: Besides the brand-name Zestoretic, we offer generic Lisinopril/HCTZ, which is just as effective and more budget friendly.

Customer Service

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How to Order Zestoretic Online in Canada?

Online

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Phone

For personalized assistance, you can place your order for Zestoretic by speaking with one of our friendly customer support representatives. Just call us on +1-877-244-0431, and we will be happy to assist you.

Fax

If you prefer using fax, you can send your prescription and details to our secure fax line at +1-877-453-0921. We ensure quick and confidential processing of your order.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019888s051lbl.pdf