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Mirapex (pramipexole)

Indications

• Mirapex Extended-Release tablets are indicated for the treatment of Parkinson’s disease, a progressive disorder of the nervous system that affects movement and muscle control.
• It is also prescribed for the management of moderate to severe primary restless legs syndrome (RLS), a neurological disorder characterized by an irresistible urge to move the legs.

Dosage and Administration

• Take Mirapex exactly as prescribed by your healthcare provider.
• Take Mirapex with or without food; however, taking it with food may help reduce nausea.
• Swallow the tablet whole with a full glass of water.
• Do not take a double dose to make up for a missed one; simply take the next dose as scheduled.
• Avoid abruptly stopping Mirapex without consulting your doctor, as this may lead to withdrawal symptoms or worsening of Parkinson’s symptoms.

Mechanism of Action

Mirapex belongs to a class of medications called dopamine agonists. They work by stimulating dopamine receptors in the brain, mimicking the effects of dopamine, a neurotransmitter involved in controlling movement and coordination. By increasing dopamine activity, Mirapex helps improve motor symptoms associated with Parkinson’s disease.

Contraindications

• Allergic Reaction: Do not take Mirapex if you have a known allergy to Pramipexole or any other ingredients in the medication.
• Severe Renal Impairment: It is contraindicated in patients with severe renal impairment (creatinine clearance less than 30 mL/min), as dosage adjustment may be necessary.
• Children: Mirapex is not recommended for use in children under the age of 18 years.

Side Effects

Common Side Effects:

• Nausea
• Dizziness
• Fatigue

Serious Side Effects:

• Hallucinations
• Impulse control disorders (such as compulsive gambling or eating)
• Orthostatic hypotension (sudden drop in blood pressure upon standing)

Precautions

• Driving and Operating Machinery: Mirapex may cause drowsiness or dizziness, so take care when driving or operating machinery until you know how the medication affects you.
• Monitor for Behavioral Changes: Be vigilant for any unusual changes in behavior, such as compulsive behaviors or hallucinations, and report them to your healthcare provider.
• Avoid Abrupt Changes: Do gradual changes in dosage under the supervision of your doctor to minimize the risk of adverse effects.

Storage Instructions

• Store Mirapex at room temperature away from moisture and heat.
• Keep the medication in its original container with the lid tightly closed to protect it from air and moisture.
• Store out of reach of children and pets to prevent accidental ingestion.

 References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020667s036lbl.pdf