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Bevespi Aerosphere (glycopyrrolate and formoterol fumarate) 

Indications 

• Bevespi Aerosphere aerosol is indicated for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. 
• It helps to improve lung function and reduce symptoms such as shortness of breath and wheezing in patients with COPD. 

Dosage and Administration 

• Shake the Bevespi Aerosphere inhaler well before each use. 
• Breathe out fully before placing the mouthpiece of the inhaler in your mouth. 
• Press down firmly on the canister to release one puff of medication, then inhale deeply and slowly. 
• Hold your breath for 10 seconds or as long as comfortable before exhaling slowly. 
• Rinse your mouth with water after using the inhaler to minimize the risk of oral thrush. 
• Do not use Bevespi Aerosphere more often than prescribed, as this may increase the risk of side effects or worsen your condition. 
• Avoid spraying the inhaler into your eyes or face. If accidental exposure occurs, rinse with water and seek medical advice if irritation persists. 
• Do not use Bevespi Aerosphere to relieve sudden symptoms of COPD. Use a rescue inhaler for rapid relief of breathing difficulties. 
• Do not stop using Bevespi Aerosphere abruptly without consulting your doctor, as it may lead to worsening of COPD symptoms. 

Mechanism of Action 

Bevespi Aerosphere combines two active ingredients: Glycopyrrolate, an anticholinergic, and Formoterol Fumarate, a long-acting beta2-adrenergic agonist (LABA). Glycopyrrolate works by relaxing the muscles around the airways, while formoterol helps to open the airways by stimulating beta2-adrenergic receptors, resulting in improved airflow and reduced symptoms of COPD. 

Contraindications 

• Do not use Bevespi Aerosphere if you are allergic to Glycopyrrolate, Formoterol, or any other components of the inhaler. 
• Avoid Bevespi Aerosphere in patients with a history of hypersensitivity reactions to anticholinergics or LABAs. 
• Consult your doctor before using the aerosol if you have a history of cardiovascular disease, hypertension, or thyroid disorders. 

Side Effects 

Common Side Effects: 

• Sore throat 
• Cough 
• Headache 
• Nausea 
• Dry mouth 

Serious Side Effects: 

• Chest pain or tightness 
• Rapid or irregular heartbeat 
• Difficulty breathing or wheezing 
• Severe allergic reactions (rash, itching, swelling, difficulty breathing) 

Precautions 

• Inform your doctor about any existing medical conditions or medications you are taking before using Bevespi Aerosphere. 
• Monitor for signs of paradoxical bronchospasm (wheezing or breathing difficulties immediately after inhalation) and discontinue use if it occurs. 
• Be cautious when driving or operating machinery until you know how Bevespi Aerosphere affects you, as it may cause dizziness or blurred vision. 

Storage Instructions 

• Store Bevespi Aerosphere inhaler at room temperature (20°C to 25°C) away from heat and direct sunlight. 
• Do not puncture or incinerate the canister, even if it is empty. 
• Keep away from open flames or sources of ignition. 
• Discard the inhaler after the expiration date printed on the packaging. 

References 

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208294s000lbl.pdf