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Jakavi (ruxolitinib phosphate)

Indications

• Myelofibrosis: Used to treat intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis.
• Polycythemia Vera: Used to treat polycythemia vera in patients who have had an inadequate response to or are intolerant of hydroxyurea.

Ingredients

• Active Ingredient: Ruxolitinib phosphate
• Inactive Ingredients: Lactose monohydrate, Microcrystalline cellulose, Croscarmellose sodium, Silicon dioxide, Magnesium stearate, Hypromellose, Titanium dioxide, Macrogol, Talc, Iron oxide yellow

Dosage and Administration

• Take Jakavi tablets exactly as prescribed by your healthcare provider.
• Swallow the tablet whole with a glass of water.
• Take it with or without food.
• Follow the dosing schedule provided by your doctor for optimal management of your condition.
• Report any missed doses to your healthcare provider and follow their instructions.
• Do not crush, chew, or split Jakavi tablets.
• Avoid consuming grapefruit or grapefruit juice during treatment, as it may increase the levels of ruxolitinib in your blood.
• Do not adjust your dosage without consulting your doctor.

Mechanism of Action

Jakavi (Ruxolitinib) is a Janus kinase (JAK) inhibitor that works by blocking the action of enzymes called Janus kinases. These enzymes play a role in the signaling pathways that regulate the production of blood cells. By inhibiting JAK1 and JAK2, Jakavi helps to reduce the abnormal production of blood cells and alleviate symptoms associated with myelofibrosis and polycythemia vera.

Contraindications

• Hypersensitivity: Do not use Jakavi if you have a known hypersensitivity to ruxolitinib or any of its components.
• Severe Liver Impairment: Avoid use in patients with severe hepatic impairment.
• Pregnancy and Breastfeeding: Jakavi may cause harm to the fetus. Avoid use during pregnancy and breastfeeding.

Side Effects

Common Side Effects

• Headache
• Dizziness
• Fatigue
• Nausea
• Diarrhea
• Upper respiratory tract infection

Serious Side Effects

• Decreased platelet counts (thrombocytopenia)
• Anemia
• Increased liver enzymes
• Worsening of infections
• Non-melanoma skin cancer
• Gastrointestinal perforation

Precautions

• Regular Monitoring: Regularly monitor blood counts, liver function, and symptoms during treatment with Jakavi.
• Infections: Inform your healthcare provider of any signs or symptoms of infection, as Jakavi may increase the risk of certain infections.
• Skin Cancer Risk: Perform regular skin examinations and protect your skin from sun exposure during treatment with Jakavi.
• Medical History: Inform your doctor about any history of liver disease, bleeding disorders, or infections.

Storage Instructions

• Store Jakavi tablets at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep the tablets in their original container, tightly closed.
• Protect from light and moisture.
• Keep out of reach of children and pets.

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Authenticity and Safety

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Prescription Requirement: We prioritize your well-being by requiring a valid prescription from a healthcare provider, ensuring that Jakavi is suitable for your condition.

Cost and Savings

Affordable Pricing: PrescriptionPoint provides some of the most competitive prices for Jakavi online, helping you reduce your drug expenses.

Generic Alternatives: Besides the brand-name Jakavi, we offer generic Ruxolitinib, which is just as effective and more budget friendly.

Customer Service

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How to Order Jakavi Online in Canada?

Online

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Phone

For personalized assistance, you can place your order for Jakavi by speaking with one of our friendly customer support representatives. Just call us on +1-877-244-0431, and we will be happy to assist you.

Fax

If you prefer using fax, you can send your prescription and details to our secure fax line at +1-877-453-0921. We ensure quick and confidential processing of your order.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/202192s023lbl.pdf