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Steglujan (ertugliflozin/sitagliptin)

Indications

Steglujan is prescribed to manage blood sugar levels in adults with type 2 diabetes, particularly when diet and exercise alone are not sufficient. It helps control blood sugar, which is essential in preventing complications like kidney damage, blindness, nerve problems, and loss of limbs.

Ingredients

• Active Ingredients: Ertugliflozin and Sitagliptin
• Inactive Ingredients: Microcrystalline cellulose, magnesium stearate, dibasic calcium phosphate anhydrous, sodium stearyl fumarate, and film coating materials (polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide).

Dosage and Administration

• Take Steglujan exactly as prescribed by your healthcare provider, generally the prescribed dose is 5 mg ertugliflozin/100 mg sitagliptin.
• Take the tablet with or without food, based on your preference or doctor’s advice.
• Check your blood sugar levels regularly to ensure the medication is working effectively.
• Drink plenty of fluids to stay hydrated, as this medication can increase urine output.
• Swallow the tablet whole
• Do not skip doses.
• Avoid alcohol as it can affect blood sugar levels and increase the risk of side effects.
• Do not crush or chew the tablets.

Mechanism of Action

Ertugliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, leading to the removal of excess glucose through urine. Sitagliptin works by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which increases the levels of incretin hormones that help regulate blood sugar by increasing insulin release and decreasing glucagon levels.

Contraindications

• Do not use it if you are allergic to Ertugliflozin, Sitagliptin, or any other ingredients in Steglujan.
• Do not use if you have severe renal impairment or end stage renal disease.
• Avoid if you have severe kidney disease or are on dialysis.
• Steglujan is not suitable for treating type 1 diabetes or diabetic ketoacidosis.
• Do not use the medication if you have severe liver disease.

Side Effects

Common Side Effects

• Urinary tract infections
• Genital yeast infections
• Increased urination
• Headache
• Diarrhea
• Nausea

Serious Side Effects

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Pancreatitis (severe abdominal pain, nausea, vomiting)
• Kidney problems (change in the amount of urine)
• Low blood sugar (hypoglycemia) symptoms such as sweating, shaking, dizziness, and confusion
• Dehydration symptoms like dizziness, fainting, and lightheadedness
• Severe joint pain

Precautions

• Inform your doctor of your complete medical history.
• Stop taking the medication if you suspect pancreatitis.
• Regular kidney function tests may be required to monitor your response to Steglujan.
• Learn to recognize symptoms of low blood sugar and how to treat it quickly.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Storage Instructions

• Store Steglujan at room temperature, between 20°C to 25°C (68°F to 77°F).
• Store in a dry place away from light and moisture.
• Keep out of reach of children and pets.
• Do not store it in the bathroom.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209805s000lbl.pdf