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Besivance (besifloxacin)

Indications

• Besivance ophthalmic suspension is prescribed for the treatment of bacterial conjunctivitis (pink eye).
• It helps to eliminate the bacteria causing the infection, reducing inflammation and relieving symptoms.

Dosage and Administration

• Wash your hands before using Besivance eye drops.
• Shake the bottle well before each use.
• Tilt your head back and pull down the lower eyelid to create a small pocket.
• Instill one drop of Besivance into the affected eye(s) every 2 hours for the first 2 days, then four times daily for the next 5 days, or as directed by your doctor.
• Blink gently to spread the medication evenly across the eye surface.
• Do not touch the tip of the Besivance dropper to any surface, including your eye, to avoid contamination.
• Do not use Besivance for longer than prescribed, as this may increase the risk of resistance.

Mechanism of Action

Besivance ophthalmic suspension contains besifloxacin, which is a fluoroquinolone antibiotic. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication and transcription. This action leads to bacterial cell death and eradication of the infection.

Contraindications

• Do not use Besivance eye drops if you are allergic to besifloxacin or any other ingredients in the suspension.
• Avoid Besivance if you have a viral or fungal eye infection, as it is only effective against bacterial infections.
• Consult your doctor before using Besivance if you are pregnant, planning to become pregnant, or breastfeeding.

Side Effects

Common Side Effects

• Eye irritation or burning sensation
• Eye redness
• Blurred vision
• Dry eyes
• Eye discomfort

Serious Side Effects

• Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Eye pain or swelling
• Increased sensitivity to light
• Changes in vision

Precautions

• Inform your doctor about any existing eye conditions or allergies before using Besivance eye drops.
• Remove contact lenses before using Besivance and wait at least 15 minutes before reinserting them.
• Do not drive or operate machinery if Besivance causes blurred vision or other visual disturbances.
• If you experience severe eye pain, changes in vision, or worsening symptoms while using Besivance, discontinue use and consult your doctor.

 Storage Instructions

• Store Besivance ophthalmic suspension at room temperature (15°C to 25°C) in its original container, tightly closed.
• Protect from light and moisture.

References

https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022308s013lbl.pdf