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Movantik (naloxegol)

Indications

Movantik is prescribed for adults experiencing constipation caused by opioid medications used to manage chronic, non-cancer pain. It helps alleviate the bowel movement issues that often accompany long-term opioid use.

Dosage and Administration

• Administer Movantik at least 1 hour before the first meal of the day or 2 hours after the meal for optimal absorption.
• Swallow the tablets whole.
• Adhere to the dosage and administration guidelines provided by your healthcare provider.
• Drink plenty of water throughout the day to support bowel movements.
• Do not crush, chew, or split the tablets to ensure the medication is delivered effectively.
• Avoid adjusting your dosage without consulting your healthcare provider, as this can affect the effectiveness and safety of the treatment.
• Avoid grapefruit and grapefruit juice as these can interfere with the absorption of Movantik, potentially increasing side effects.
• Take Movantik consistently as prescribed to maintain its effectiveness.

Mechanism of Action

Movantik (Naloxegol) is a peripherally acting mu-opioid receptor antagonist (PAMORA). It works by selectively blocking the opioid receptors in the gastrointestinal tract without affecting the pain-relief functions of opioids in the central nervous system. This action helps restore normal bowel function without diminishing pain relief.

Contraindications

• Known Hypersensitivity to Naloxegol: Do not take Movantik if you have a known allergy to Naloxegol or any of its components.
• Bowel Obstruction: Avoid using Movantik if you have a history of bowel obstruction or are at high risk of developing this condition.
• Severe Liver Impairment: Patients with severe liver problems should not take Movantik as it may exacerbate their condition.

Side Effects

Common Side Effects:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Gas

Serious Side Effects:

• Severe abdominal pain
• Persistent diarrhea
• Symptoms of a serious allergic reaction (rash, itching/swelling, severe dizziness, trouble breathing)

Precautions

• Consult Your Doctor if Pregnant or Breastfeeding: Discuss with your healthcare provider before starting Movantik if you are pregnant or planning to breastfeed.
• Inform About All Medications: Share a complete list of your current medications with your doctor to avoid harmful interactions.
• Monitor for Severe Abdominal Pain: Contact your healthcare provider if you experience severe, persistent abdominal pain, as this could indicate a serious condition.
• Adjust for Kidney Problems: Your doctor may need to adjust your dose if you have kidney issues.
• Avoid Driving if Drowsy: Movantik can cause dizziness; ensure you know how it affects you before driving or operating machinery.

Storage Instructions

• Keep Movantik tablets at 68°F to 77°F (20°C to 25°C).
• Store the medication in its original container to protect it from moisture and light.
• Ensure that Movantik is stored in a safe place away from children to prevent accidental ingestion.

References

https://movantik.com/pdf/MovantikPrescribingInformation.pdf